Publications

Relevant publications from members of the Microbiology Consortium:

Clarke DJ, Mackay CL, Campopiano DJ, Langridge-Smith P & Brown AR (2009) Interrogating the molecular details of the peroxiredoxin activity of Escherichia coli bacterioferritin comigratory protein using high-resultion mass spectrometry. Biochem. 48(12), 3904-3914. Abstract

Loutet SA, Bartholdson SJ, Govan JR, Campopiano DJ & Valvano MA (2009) Contributions of two UDP-glucose dehydrogenases to viability and polymyxin B resistance of Burkholderia cenocepacia. Microbiol. 155(6), 2029-2039. Abstract

Rose H, Baldwin A, Dowson CG, Mahenthiralingam E (2009) Biocide susceptibility of the Burkholderia cepacia complex. J. Antimicrob. Chemother. 63(3), 502-510 Abstract

Winstanley C, Langille MG, Fothergill JL, Kukavica-Ibrulj I, Paradis-Bleau C, Sanschagrin F, Thomson NR, Winsor GL, Quail MA, Lennard N, Bignell A, Clarke L, Seeger K, Saunders D, Harris D, Parkhill J, Hancock RE, Brinkman FS, Levesque RC. (2009) Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa. Genome Res. 19(1), 12-23. Abstract

Winstanley C, Fothergill JL. (2009) The role of quorum-sensing in chronic cystic fibrosis Pseudomonas aeruginosa infections. FEMS Microbiol. Lett. 290(1), 1-9. Abstract

Mohan K, Fothergill JL, Storrar J, Ledson MJ, Winstanley C, Walshaw MJ. (2008) Transmission of Pseudomonas aeruginosa epidemic strain from a patient with cystic fibrosis to a pet cat.. Thorax 63(9), 839-840 Abstract

Bartholdson SJ, Brown AR, Mewburn BR, Clarke DJ, Fry SC, Campopiano DJ, Govan JR (2008) Plant host and sugar alcohol induced exopolysaccharide biosynthesis in the Burkholderia cepacia complex. Microbiology. 154, 2513-2521 Abstract

Fothergill JL, Upton AL, Pitt TL, Hart CA, Winstanley C (2008) Diagnostic multiplex PCR assay for the identification of the Liverpool, Midlands-1 and Manchester CF epidemic strains of Pseudomonas aeruginosa. J. Cyst. Fibros. 7, 258-261 Abstract

Taylor K, McCullough B, Clarke DJ, Langley RJ, Pechenik T, Hill A, Campopiano DJ, Barran PE, Dorin JR, Govan JR (2007) Covalent dimer species of beta-defensin Defr1 display potent antimicrobial activity against multidrug-resistant bacterial pathogens. Antimicrob. Agents Chemother. 51, 1719-1724 Abstract

Fothergill JL, Panagea S, Hart CA, Walshaw MJ, Pitt TL, Winstanley C (2007) Widespread pyocyanin over-production among isolates of a cystic fibrosis epidemic strain. BMC Microbiol. 7, 45 Abstract Full text

Brown AR, Govan JR (2007) Assessment of fluorescent in situ hybridization and PCR-based methods for the rapid identification of Burkholderia cepacia complex organisms directly from sputum samples. J. Clin. Microbiol. 45, 1920-1926. Abstract

Weisner AM, Chart H, Bush A, Davies JC, Pitt TL (2007) Detection of antibodies to Pseudomonas aeruginosa in serum and oral fluid from patients with cystic fibrosis. J. Med. Microbiol. 56, 670-674. Abstract

Ortega XP, Cardona ST, Brown AR, Loutet SA, Flannagan RS, Campopiano DJ, Govan JR, Valvano MA. (2007) A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability. J. Bacteriol. 189, 3639-3644. Abstract

Govan JR, Brown AR & Jones AM (2007) Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection. Future Microbiol. 2, 153-164. Abstract

Smart CHM, Scott FW, Wright EA, Walshaw MJ, Hart CA, Pitt TL, Winstanley C. (2006) Development of a diagnostic test for the Midlands-1 cystic fibrosis epidemic strain of Pseudomonas aeruginosa. J. Med. Microbiol. 55, 1085-1091. Abstract

Markey KM, Glendinning KJ, Morgan JAW, Hart CA, Winstanley C. (2006) Caenorhabditis elegans killing assay as an infection model to study the role of type III secretion system in Burkholderia cenocepacia. J. Med. Microbiol. 55, 967-969.

Smart CHM, Walshaw MJ, Hart CA, Winstanley C. (2006) Use of suppression subtractive hybridisation to examine the accessory genome of the Liverpool cystic fibrosis epidemic strain of Pseudomonas aeruginosa. J. Med. Microbiol. 55, 677-688. Abstract

Assaad W, Magalhaes M, Plesa M, Hart CA, Cornelis P, Winstanley C. (2006) Identical Burkholderia cepacia complex strain types isolated from multiple patients attending a hospital in Brazil. J. Med. Microbiol. 55, 247-249.

Martin SL, Downey D, Bilton D, Keogan MT, Edgar J, Elborn JS. (2006) Safety and efficacy of recombinant alpha1-antitrypsin therapy in cystic fibrosis. Ped. Pulmonol. 41,177-183. Abstract

Baldwin A, Mahenthiralingam E, Thickett KM, Honeybourne D, Maiden MC, Govan JR, Speert DP, Lipuma JJ, Vandamme P, Dowson CG. (2005). Multilocus sequence typing scheme that provides both species and strain differentiation for the Burkholderia cepacia complex. J. Clin. Microbiol. 43, 4665-73. Abstract

Chambers D, Scott F, Bangur R, Davis R, Lim A, Walters S, Smith G, Pitt TL, Stableforth D, Honeybourne D. (2005). Factors associated with infection by Pseudomonas aeruginosa in adult cystic fibrosis. European Respiratory Journal 26, 651-656. Abstract

Lewis DA, Jones A, Parkhill J, Speert DP, Govan JR, Lipuma JJ, Lory S, Webb AK, Mahenthiralingam E. (2005). Identification of DNA Markers for a Transmissible Pseudomonas aeruginosa. Cystic Fibrosis Strain. Am. J. Respir. Cell. Mol. Biol. 33, 56-64. Abstract

Mahenthiralingam E, Urban TA, Goldberg JB. (2005). The multifarious, multireplicon Burkholderia cepacia complex. Nat Rev Microbiol 3, 144-56. Abstract

McMichael JW, Maxwell AI, Hayashi K, Taylor K, Wallace WA, Govan JRW, Dorin JR, Sallenave J-M. (2005). Antimicrobial activity of murine lung cells against Staphylococcus aureus is increased in vitro and in vivo after elafin transfer. Infect. Immun. 73, 3609-3617. Abstract

Panagea S, Winstanley C, Walshaw MJ, Ledson MJ, Hart CA (2005). Environmental contamination with an epidemic strain of Pseudomonas aeruginosa in a Liverpool cystic fibrosis centre and study of its survival on dry surfaces. J. Hosp. Inf. 59, 102-107. Abstract

Salunkhe P, Smart CHM, Morgan JAW, Panagea S, Walshaw MJ, Hart CA, Geffers R, Tümmler B, Winstanley C. (2005). A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. J. Bacteriol. 187, 4908-4920. Abstract

Al-Aloul M, Crawley J, Winstanley C, Hart CA, Ledson MJ, Walshaw MJ (2004). Increased morbidity associated with colonization by an epidemic Pseudomonas aeruginosa strain in cystic fibrosis patients. Thorax 59, 334-336. Abstract

Baldwin A, Sokol PA, Parkhill J, Mahenthiralingam E. (2004). The Burkholderia cepacia epidemic strain marker is part of a novel genomic island encoding both virulence and metabolism-associated genes in Burkholderia cenocepacia. Infect. Immun. 72, 1537-1547. Abstract

Campopiano DJ, Clarke DJ, Polfer NC, Barran PE, Langley RJ, Govan JRW, Maxwell A, Dorin J. (2004) Structure-activity relationships in defensin dimers. A novel link between b-defensin tertiary structure and antimicrobial activity. J. Biol. Chem. 279, 48671-48679 Abstract

De Soyza A, Morris K, McDowell A, Doherty C, Archer L, Perry J, Govan JRW, Corris PA, Gould KF. (2004) Prevalence and clonality of Burkholderia cepacia complex genomovars in United Kingdom cystic fibrosis patients referred for lung transplantation. Thorax 59, 526-528. Abstract

McDowell A, Mahenthiralingam E, Dunbar KEA, Moore JE, Crowe M, Elborn S. (2004) Epidemiology of Burkholderia cepacia complex species recovered from cystic fibrosis patients: Issues related to patient segregation. J Med Micro. 53, 663-668. Abstract

Scott FW & Pitt TL (2004). Identification and characterization of transmissible Pseudomonas aeruginosa strains in cystic fibrosis patients in England and Wales. J. Med. Microbiol. 53, 609-615. Abstract

Panagea S, Winstanley C, Parsons YN, Walshaw MJ, Ledson MJ, Hart CA (2003). PCR-based detection of a cystic fibrosis epidemic strain of Pseudomonas aeruginosa. Molecular Diagnosis 7:195-200. Abstract

Dinesh SD, Grundmann H, Pitt TL, Romling U. (2003). European-wide distribution of Pseudomonas aeruginosa clone C. Clinical Microbiology & Infection 9, 1228-1233. Abstract

Jones AM, Martin L, Bright-Thomas RJ, Dodd ME, McDowell A, Moffitt KL, Elborn JS, Webb AK (2003) Inflammatory markers in cystic fibrosis patients with transmissible Pseudomonas aeruginosa. Eur Respir J. 22, 503-506. Abstract

Parsons YN, Panagea S, Smart CHM, Walshaw MJ, Hart CA, Winstanley C. (2002) Use of subtractive hybridization to identify a diagnostic probe for a cystic fibrosis epidemic strain of Pseudomonas aeruginosa. J. Clin. Microbiol. 40, 4607-4611. Abstract

Scott CJ, McDowell A, Martin SL, Lynas JF, Vandenbroeck K, Walker B. (2002) Irreversible inhibition of the bacterial cysteine protease-transpeptidase sortase (SrtA) by substrate-derived affinity labels. Biochem J. 366, 953-958. Abstract

De Soyza A, McDowell A, Archer L, Dark JH, Elborn SJ, Mahenthiralingam E, Gould K, Corris PA (2001) Burkholderia cepacia complex genomovars and pulmonary transplantation outcomes in patients with cystic fibrosis. Lancet 358,1780-1781. Abstract

Mahenthiralingam E, Vandamme P, Campbell ME, Henry DA, Gravelle AM, Wong LT, Davidson AG, Wilcox PG, Nakielna B, Speert DP. (2001). Infection with Burkholderia cepacia complex genomovars in patients with cystic fibrosis: Virulent transmissible strains of genomovar III can replace Burkholderia multivorans. Clin. Infect. Dis. 33, 1469-75. Abstract

McDowell A, Mahenthiralingam E, Moore JE, Dunbar KEA, Webb AK, Dodd ME, Martin SL, Millar BC, Scott CJ, Crowe M, Elborn JS. (2001) PCR-based detection and identification of Burkholderia cepacia complex pathogens in sputum from cystic fibrosis patients. J Clin Microbiol. 39,4247-4255. Abstract

Mahenthiralingam E, Bischof J, Byrne SK, Radomski C, Davies JE, Av-Gay Y, Vandamme P. (2000). DNA-Based diagnostic approaches for identification of Burkholderia cepacia complex, Burkholderia vietnamiensis, Burkholderia multivorans, Burkholderia stabilis, and Burkholderia cepacia genomovars I and III. J. Clin. Microbiol. 38, 3165-73. Abstract