Publications

Recent relevant publications from members of the Microbiology Consortium:

Fothergill JL, Mowat E, Walshaw MJ, Ledson MJ, James CE & Winstanley C (2011) Effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa. Antimicrob. Agents & Chemother. 55(1), 426-428. Abstract

Tunney MM, Klem ER, Fodor AA, Gilpin DF, Moriarty TF, McGrath SJ, Muhlebach MS, Boucher RC, Cardwell C, Doering G, Elborn JS & Wolfgang MC (2011) Use of culture and molecular analysis to determine the effect of antibiotic treatment on microbial community diversity and abundance during exacerbation in patients with cystic fibrosis. Thorax [Epub ahead of print]. Abstract

Carter ME, Fothergill JL, Walshaw MJ, Rajakumar K, Kadioglu A & Winstanley C (2010) A subtype of a Pseudomonas aeruginosa cystic fibrosis epidemic strain exhibits enhanced virulence in a murine model of acute respiratory infection. J. Infect. Dis. 202(6), 935-942. Abstract

Fothergill JL, White J, Foweraker JE, Walshaw MJ, Ledson MJ, Mahenthiralingam E & Winstanley C (2010) Impact of Pseudomonas aeruginosa genomic instability on the application of typing methods for chronic cystic fibrosis infections. J. Clin. Microbiol. 48(6), 2053-2059. Abstract

Mohan K, Lakshman V, Fothergill JL, Ledson MJ, Winstanley C & Walshaw MJ (2010) Empyema due to a highly transmissible Pseudomonas aeruginosa strain in an adult cystic fibrosis patient. J. Med. Microbiol. 59(5), 614-616. Abstract

Fothergill JL, Mowat E, Ledson MJ, Walshaw MJ & Winstanley C (2010) Fluctuations in phenotypes and genotypes within populations of Pseudomonas aeruginosa in the cystic fibrosis lung during pulmonary exacerbations. J. Med. Microbiol. 59(4), 472-481. Abstract

Clarke DJ, Ortega XP, Mackay CL, Valvano MA, Govan JR, Campopiano DJ, Langridge-Smith P & Brown AR (2010) Subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins based on catalytic activity. Biochem. 49(6), 1319-1330. Abstract

Drevinek P, Baldwin A, Lindenburg L, Joshi LT, Marchbank A, Vosahlikova S, Dowson CG & Mahenthiralingam E (2010) Oxidative stress of Burkholderia cenocepacia induces insertion sequence-mediated genomic rearrangements that interfere with macrorestriction-based genotyping. J. Clin. Microbiol. 48(1), 34-40. Abstract

Loutet SA, Bartholdson SJ, Govan JR, Campopiano DJ & Valvano MA (2009) Contributions of two UDP-glucose dehydrogenases to viability and polymyxin B resistance of Burkholderia cenocepacia. Microbiol. 155(6), 2029-2039. Abstract

Rose H, Baldwin A, Dowson CG, Mahenthiralingam E (2009) Biocide susceptibility of the Burkholderia cepacia complex. J. Antimicrob. Chemother. 63(3), 502-510 Abstract

Winstanley C, Langille MG, Fothergill JL, Kukavica-Ibrulj I, Paradis-Bleau C, Sanschagrin F, Thomson NR, Winsor GL, Quail MA, Lennard N, Bignell A, Clarke L, Seeger K, Saunders D, Harris D, Parkhill J, Hancock RE, Brinkman FS, Levesque RC. (2009) Newly introduced genomic prophage islands are critical determinants of in vivo competitiveness in the Liverpool Epidemic Strain of Pseudomonas aeruginosa. Genome Res. 19(1), 12-23. Abstract

Winstanley C, Fothergill JL. (2009) The role of quorum-sensing in chronic cystic fibrosis Pseudomonas aeruginosa infections. FEMS Microbiol. Lett. 290(1), 1-9. Abstract

Mohan K, Fothergill JL, Storrar J, Ledson MJ, Winstanley C, Walshaw MJ. (2008) Transmission of Pseudomonas aeruginosa epidemic strain from a patient with cystic fibrosis to a pet cat. Thorax 63(9), 839-840 Abstract

Drevinek P, Holden MT, Ge Z, Jones AM, Ketchell I, Gill RT & Mahenthiralingam E (2008) Gene expression changes linked to antimicrobial resistance, oxidative stress, iron depletion and retained motility are observed when Burkholderia cenocepacia grows in cystic fibrosis sputum. BMC Infect. Dis. 8, 121 Abstract

Tunney MM, Field TR, Moriarty TF, Patrick S, Doering G, Muhlebach MS, Wolfgang MC, Boucher RC, Gilpin DF, McDowell A & Elborn JS (2008) Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis. Am. J. Respir. Crit. Care Med. 177(9), 995-1001 Abstract

Bartholdson SJ, Brown AR, Mewburn BR, Clarke DJ, Fry SC, Campopiano DJ, Govan JR (2008) Plant host and sugar alcohol induced exopolysaccharide biosynthesis in the Burkholderia cepacia complex. Microbiology. 154, 2513-2521 Abstract

Fothergill JL, Upton AL, Pitt TL, Hart CA, Winstanley C (2008) Diagnostic multiplex PCR assay for the identification of the Liverpool, Midlands-1 and Manchester CF epidemic strains of Pseudomonas aeruginosa. J. Cyst. Fibros. 7, 258-261 Abstract

Taylor K, McCullough B, Clarke DJ, Langley RJ, Pechenik T, Hill A, Campopiano DJ, Barran PE, Dorin JR, Govan JR (2007) Covalent dimer species of beta-defensin Defr1 display potent antimicrobial activity against multidrug-resistant bacterial pathogens. Antimicrob. Agents Chemother. 51, 1719-1724 Abstract

Fothergill JL, Panagea S, Hart CA, Walshaw MJ, Pitt TL, Winstanley C (2007) Widespread pyocyanin over-production among isolates of a cystic fibrosis epidemic strain. BMC Microbiol. 7, 45 Abstract Full text

Brown AR, Govan JR (2007) Assessment of fluorescent in situ hybridization and PCR-based methods for the rapid identification of Burkholderia cepacia complex organisms directly from sputum samples. J. Clin. Microbiol. 45, 1920-1926. Abstract

Weisner AM, Chart H, Bush A, Davies JC, Pitt TL (2007) Detection of antibodies to Pseudomonas aeruginosa in serum and oral fluid from patients with cystic fibrosis. J. Med. Microbiol. 56, 670-674. Abstract

Ortega XP, Cardona ST, Brown AR, Loutet SA, Flannagan RS, Campopiano DJ, Govan JR, Valvano MA. (2007) A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability. J. Bacteriol. 189, 3639-3644. Abstract

Govan JR, Brown AR & Jones AM (2007) Evolving epidemiology of Pseudomonas aeruginosa and the Burkholderia cepacia complex in cystic fibrosis lung infection. Future Microbiol. 2, 153-164. Abstract

Smart CHM, Scott FW, Wright EA, Walshaw MJ, Hart CA, Pitt TL, Winstanley C. (2006) Development of a diagnostic test for the Midlands-1 cystic fibrosis epidemic strain of Pseudomonas aeruginosa. J. Med. Microbiol. 55, 1085-1091. Abstract

Smart CHM, Walshaw MJ, Hart CA, Winstanley C. (2006) Use of suppression subtractive hybridisation to examine the accessory genome of the Liverpool cystic fibrosis epidemic strain of Pseudomonas aeruginosa. J. Med. Microbiol. 55, 677-688. Abstract

Baldwin A, Mahenthiralingam E, Thickett KM, Honeybourne D, Maiden MC, Govan JR, Speert DP, Lipuma JJ, Vandamme P, Dowson CG. (2005). Multilocus sequence typing scheme that provides both species and strain differentiation for the Burkholderia cepacia complex. J. Clin. Microbiol. 43, 4665-73. Abstract

Chambers D, Scott F, Bangur R, Davis R, Lim A, Walters S, Smith G, Pitt TL, Stableforth D, Honeybourne D. (2005). Factors associated with infection by Pseudomonas aeruginosa in adult cystic fibrosis. European Respiratory Journal 26, 651-656. Abstract

Lewis DA, Jones A, Parkhill J, Speert DP, Govan JR, Lipuma JJ, Lory S, Webb AK, Mahenthiralingam E. (2005). Identification of DNA Markers for a Transmissible Pseudomonas aeruginosa. Cystic Fibrosis Strain. Am. J. Respir. Cell. Mol. Biol. 33, 56-64. Abstract

Mahenthiralingam E, Urban TA, Goldberg JB. (2005). The multifarious, multireplicon Burkholderia cepacia complex. Nat Rev Microbiol 3, 144-56. Abstract

Panagea S, Winstanley C, Walshaw MJ, Ledson MJ, Hart CA (2005). Environmental contamination with an epidemic strain of Pseudomonas aeruginosa in a Liverpool cystic fibrosis centre and study of its survival on dry surfaces. J. Hosp. Inf. 59, 102-107. Abstract

Salunkhe P, Smart CHM, Morgan JAW, Panagea S, Walshaw MJ, Hart CA, Geffers R, Tümmler B, Winstanley C. (2005). A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. J. Bacteriol. 187, 4908-4920. Abstract